Computer Engineeringelectronics Engineering Civil Engineering |
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One of the major challenges of biomarker profiling with proteomic chips (protein arrays) is the availability of chip surfaces providing sufficient analytical sensitivity for customer applications where starting material is very limited or expensive (e.g. for cancer tissue, stem cells, etc.). The goal of this project is to develop a novel 3D micro- and nanostructured surface for planar waveguide proteomic chips. The micro-patterning techique explored in this project will then be combined with sub-micron surface chemistry, developed in the sister project Vesicle and Particle Assays for Protein Microarray Application, to finally achieve a 100-fold increased sensitivity for protein microarrays. |
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